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Restless Leg Syndrome

Medically reviewed by John Sammis, D.O.
A woman in a peach sweater and light blue pants rubs her leg with a pained expression. Her brown hair falls to one side as she leans forward.
11 min read

Restless Leg Syndrome (RLS) is a neurological disorder that causes an uncontrollable urge to move the legs. It is a common condition that affects up to 10% of the population. RLS is more common in women than men and is more likely to occur in people over the age of 40. It is also more common in people with certain medical conditions, such as diabetes, kidney disease, and iron deficiency.

RLS is a chronic condition that can cause significant disruption to a person's quality of life. It can interfere with sleep, work, and other activities. It can also lead to feelings of anxiety and depression. The exact cause of RLS is unknown, but it is believed to be related to an imbalance of certain chemicals in the brain.

Diagnosis of RLS is based on a person's symptoms and medical history. There is no single test that can diagnose RLS. Treatment of RLS typically involves lifestyle changes, such as avoiding caffeine and alcohol, and medications. In some cases, physical therapy or other treatments may be recommended.

Take the Restless Leg Syndrome Assessment

Symptoms

  • Uncomfortable sensations in the legs, such as tingling, burning, itching, or aching
  • An urge to move the legs, usually accompanied by an uncomfortable sensation
  • Difficulty falling asleep or staying asleep due to the urge to move the legs
  • Increased symptoms at night or during periods of inactivity
  • Daytime fatigue due to lack of sleep

If you are experiencing any of these symptoms, it is important to talk to your doctor. They can help you determine if you have RLS and provide treatment options to help manage your symptoms.

Causes

Genetics

RLS is believed to have a genetic component, as it is more common in people with a family history of the disorder. Studies have shown that up to 60% of people with RLS have a family member with the condition. Additionally, certain genetic mutations have been linked to RLS, suggesting that it may be inherited.

Iron Deficiency

Iron deficiency is one of the most common causes of RLS. Iron is an essential mineral that helps the body produce dopamine, a neurotransmitter that helps regulate movement. Low levels of iron can lead to a decrease in dopamine, which can cause the symptoms of RLS. Iron deficiency can be caused by a poor diet, certain medical conditions, or blood loss.

Pregnancy

Pregnancy is another common cause of RLS. During pregnancy, the body undergoes many hormonal and physiological changes, which can lead to an increase in RLS symptoms. Additionally, iron deficiency is more common during pregnancy, which can further contribute to the development of RLS.

Medications

Certain medications can also cause RLS. Antidepressants, antipsychotics, and anti-nausea medications are among the most common culprits. Additionally, some medications used to treat high blood pressure, such as beta-blockers, can also cause RLS.

Other Causes

Other potential causes of RLS include kidney failure, diabetes, and certain neurological conditions. Additionally, alcohol and caffeine consumption can worsen the symptoms of RLS.

While the exact cause of RLS is unknown, there are several factors that may contribute to its development. Genetics, iron deficiency, pregnancy, medications, and other medical conditions can all play a role in the development of RLS.

Getting a Diagnosis

Medical History

The first step in diagnosing RLS is to take a detailed medical history. Your doctor will ask about your symptoms, when they started, and how often they occur. They will also ask about any other medical conditions you may have, as well as any medications you are taking. This information will help your doctor determine if RLS is the most likely cause of your symptoms.

Physical Exam

Your doctor may also perform a physical exam to rule out other conditions. This may include checking your reflexes, muscle strength, and sensation in your legs. Your doctor may also order blood tests to check for anemia or other conditions that can cause similar symptoms.

Sleep Study

Your doctor may also recommend a sleep study to rule out other sleep disorders. During a sleep study, you will be monitored while you sleep to look for signs of RLS. This may include measuring your brain waves, heart rate, and breathing patterns.

Treatment

Once your doctor has diagnosed RLS, they will recommend a treatment plan. This may include lifestyle changes, such as exercising regularly and avoiding caffeine and alcohol. Your doctor may also prescribe medications to help reduce the symptoms of RLS. In some cases, surgery may be recommended to treat the underlying cause of RLS.

Questions for Your Doctor

Symptoms

Describe your symptoms to your doctor. Be sure to include when they started, how often they occur, and how long they last. Also, mention any other symptoms you may be experiencing, such as pain, numbness, or tingling in your legs.

Family History

RLS can be hereditary, so it’s important to tell your doctor if anyone in your family has been diagnosed with it. This can help your doctor determine if you are at risk for developing RLS.

Medications

Tell your doctor about any medications you are taking, including over-the-counter drugs and supplements. Some medications can worsen RLS symptoms, so it’s important to let your doctor know what you are taking.

Lifestyle Changes

Your doctor may suggest lifestyle changes to help manage your RLS symptoms. These may include avoiding caffeine and alcohol, exercising regularly, and getting enough sleep. Be sure to discuss any changes you can make to your lifestyle to help manage your RLS.

Treatment Options

Your doctor may suggest medications or other treatments to help manage your RLS symptoms. Be sure to ask your doctor about the risks and benefits of any treatment options they suggest.

Follow-Up Appointments

Your doctor may want to monitor your RLS symptoms over time. Be sure to ask your doctor how often you should schedule follow-up appointments.

Treatment

Medication

Medication is the most common treatment for RLS. The most commonly prescribed medications are dopamine agonists, which help to increase dopamine levels in the brain. Other medications, such as anticonvulsants, opioids, and benzodiazepines, may also be prescribed. It is important to talk to your doctor about the potential side effects of any medication before taking it.

Lifestyle Changes

Making lifestyle changes can also help to reduce the symptoms of RLS. Avoiding caffeine, alcohol, and nicotine can help to reduce the intensity of symptoms. Regular exercise can also help to reduce the symptoms of RLS. Additionally, getting enough sleep and managing stress can help to reduce the symptoms of RLS.

Alternative Treatments

There are also alternative treatments that may help to reduce the symptoms of RLS. Acupuncture, massage, and yoga can help to reduce the symptoms of RLS. Additionally, taking supplements such as iron, magnesium, and vitamin B12 can help to reduce the symptoms of RLS.

Conclusion

Restless Leg Syndrome can be a difficult condition to manage, but there are treatments available to help reduce the symptoms. Medication, lifestyle changes, and alternative treatments can all help to reduce the symptoms of RLS. It is important to talk to your doctor about the best treatment plan for you.

Drugs & Medications

Dopamine Agonists

Dopamine agonists are the most commonly prescribed medications for RLS. These drugs work by increasing the amount of dopamine in the brain, which helps to reduce the symptoms of RLS. Examples of dopamine agonists include pramipexole, ropinirole, and rotigotine.

Benzodiazepines

Benzodiazepines are a class of drugs that are used to treat anxiety and insomnia. They can also be used to treat RLS, as they help to relax the muscles and reduce the urge to move the legs. Examples of benzodiazepines include clonazepam, diazepam, and lorazepam.

Anticonvulsants

Anticonvulsants are drugs that are used to treat seizures. They can also be used to treat RLS, as they help to reduce the symptoms of the disorder. Examples of anticonvulsants include gabapentin, pregabalin, and carbamazepine.

Opioids

Opioids are a class of drugs that are used to treat pain. They can also be used to treat RLS, as they help to reduce the symptoms of the disorder. Examples of opioids include oxycodone, hydrocodone, and morphine.

Conclusion

There are several medications available to help manage the symptoms of RLS. Dopamine agonists, benzodiazepines, anticonvulsants, and opioids are all commonly prescribed medications for RLS. It is important to speak to your doctor before taking any medication, as some medications may have side effects or interact with other medications.

Diet

Foods to Avoid

Certain foods can worsen the symptoms of RLS, so it is important to avoid them. Caffeine, alcohol, and nicotine can all make RLS worse, so it is best to avoid them. Processed foods, such as white bread, pasta, and pastries, can also worsen RLS symptoms, so it is best to limit these foods. Additionally, foods high in sugar and saturated fat should be avoided.

Foods to Include

Including certain foods in the diet can help reduce the symptoms of RLS. Foods high in magnesium, such as spinach, almonds, and black beans, can help reduce RLS symptoms. Iron-rich foods, such as lean red meat, eggs, and fortified cereals, can also help. Additionally, foods high in B vitamins, such as whole grains, legumes, and leafy greens, can help reduce RLS symptoms.

Conclusion

Making dietary changes can help reduce the symptoms of RLS. It is important to avoid foods that can worsen RLS symptoms, such as caffeine, alcohol, nicotine, processed foods, and foods high in sugar and saturated fat. Additionally, it is important to include foods that can help reduce RLS symptoms, such as magnesium-rich foods, iron-rich foods, and foods high in B vitamins.

Lifestyle

Exercise Regularly

Regular exercise can help reduce the symptoms of RLS. Aim for at least 30 minutes of moderate-intensity exercise, such as walking, jogging, or swimming, three to five times a week. Exercise can help reduce stress and improve sleep quality, both of which can help reduce RLS symptoms.

Avoid Caffeine and Alcohol

Caffeine and alcohol can both worsen RLS symptoms. Try to limit your intake of both, or avoid them altogether if possible. If you do choose to drink alcohol, do so in moderation.

Get Enough Sleep

Getting enough sleep is essential for managing RLS symptoms. Aim for seven to nine hours of sleep each night. If you have trouble sleeping, try to establish a regular sleep schedule and avoid activities that can interfere with sleep, such as watching television or using a computer late at night.

Manage Stress

Stress can worsen RLS symptoms, so it’s important to find ways to manage stress. Try relaxation techniques such as yoga, meditation, or deep breathing. You can also try to limit your exposure to stressful situations and take time for yourself to relax.

Eat a Healthy Diet

Eating a healthy diet can help reduce RLS symptoms. Aim to eat a balanced diet that includes plenty of fruits, vegetables, whole grains, and lean proteins. Avoid processed foods and foods high in sugar and saturated fat. Eating a healthy diet can also help you maintain a healthy weight, which can help reduce RLS symptoms.

Talk to Your Doctor

If lifestyle changes don’t help reduce your RLS symptoms, talk to your doctor. They may be able to prescribe medications or suggest other treatments that can help manage your symptoms.