Non-Hodgkin's Lymphoma

11 min read

Non-Hodgkin's lymphoma (NHL) is a type of cancer that affects the lymphatic system, which is part of the body's immune system. It is a cancer of the lymphocytes, which are a type of white blood cell. NHL is the seventh most common cancer in the United States, and it is estimated that more than 70,000 new cases are diagnosed each year.

Types of Non-Hodgkin's Lymphoma

NHL is divided into two main categories: indolent (slow-growing) and aggressive (fast-growing). Indolent NHL is typically slow-growing and may not require treatment for many years. Aggressive NHL is fast-growing and requires more aggressive treatment. NHL can also be divided into subtypes based on the type of lymphocyte affected. These subtypes include B-cell lymphomas, T-cell lymphomas, and natural killer cell lymphomas.

Causes of Non-Hodgkin's Lymphoma

The exact cause of NHL is unknown, but there are several factors that may increase a person's risk of developing the disease. These include a weakened immune system, exposure to certain chemicals, and certain viral infections. People with a family history of NHL may also be at an increased risk.

Diagnosis of Non-Hodgkin's Lymphoma

NHL is typically diagnosed through a combination of physical exams, imaging tests, and biopsies. A physical exam may reveal swollen lymph nodes, which can be a sign of NHL. Imaging tests, such as CT scans and MRIs, can help doctors determine the size and location of any tumors. A biopsy is the only way to definitively diagnose NHL.

Prognosis of Non-Hodgkin's Lymphoma

The prognosis for NHL depends on the type and stage of the disease. Indolent NHL is typically slow-growing and may not require treatment for many years. Aggressive NHL is fast-growing and requires more aggressive treatment. The overall five-year survival rate for NHL is approximately 70%.

Symptoms

  • Swollen lymph nodes in the neck, armpits, or groin
  • Unexplained weight loss
  • Fever
  • Night sweats
  • Fatigue
  • Itching
  • Abdominal pain or swelling
  • Coughing or difficulty breathing
  • Chest pain
  • Shortness of breath

If you experience any of these symptoms, it is important to see your doctor right away. Your doctor will be able to diagnose Non-Hodgkin's lymphoma and recommend the best treatment plan for you.

Take the Non-Hodgkin's Lymphoma Assessment

Causes

Age

Non-Hodgkin's lymphoma is more common in people over the age of 60. The risk of developing the disease increases with age.

Gender

Non-Hodgkin's lymphoma is more common in men than in women.

Infections

Certain infections, such as the Epstein-Barr virus, human T-cell lymphotropic virus type 1, and Helicobacter pylori, have been linked to an increased risk of Non-Hodgkin's lymphoma.

Immune System Disorders

People with weakened immune systems, such as those with HIV/AIDS or those who have had an organ transplant, are at an increased risk of developing Non-Hodgkin's lymphoma.

Exposure to Chemicals

Exposure to certain chemicals, such as herbicides, pesticides, and solvents, may increase the risk of Non-Hodgkin's lymphoma.

Family History

Having a family history of Non-Hodgkin's lymphoma may increase a person's risk of developing the disease.

Getting a Diagnosis

Physical Exam

The first step in diagnosing NHL is a physical exam. During the exam, the doctor will look for swollen lymph nodes, which can be a sign of NHL. The doctor may also feel for any lumps or bumps in the abdomen, chest, or neck. The doctor may also order blood tests to check for signs of infection or other conditions.

Imaging Tests

Imaging tests such as X-rays, CT scans, and MRIs can be used to look for tumors or other abnormalities in the body. These tests can help the doctor determine the size and location of any tumors, as well as whether they have spread to other parts of the body.

Biopsy

A biopsy is the only way to definitively diagnose NHL. During a biopsy, a small sample of tissue is taken from the affected area and examined under a microscope. This can help the doctor determine the type of NHL and whether it is aggressive or slow-growing.

Conclusion

Diagnosing NHL can be a complex process, but it is important to get an accurate diagnosis as soon as possible. A combination of physical exams, imaging tests, and biopsies can help the doctor determine the type and stage of NHL and begin treatment.

Questions for Your Doctor

Diagnosis and Staging

Your doctor will need to determine the type of Non-Hodgkin's lymphoma you have and the stage of the disease. This will help them determine the best course of treatment. Ask your doctor to explain the diagnosis and staging process and what it means for your treatment.

Treatment Options

Your doctor will discuss the various treatment options available to you. Ask them to explain the pros and cons of each option and how they will affect your quality of life. Make sure to ask about any potential side effects and how they can be managed.

Follow-up Care

Your doctor will likely recommend follow-up care after treatment. Ask them to explain what this will involve and how often it will need to be done. Make sure to ask about any lifestyle changes you may need to make to reduce your risk of recurrence.

Support Services

Your doctor may be able to refer you to support services such as counseling, support groups, or financial assistance. Ask them to explain what services are available and how to access them.

Questions and Concerns

Make sure to ask your doctor any questions or concerns you may have about your diagnosis and treatment. It is important to have an open and honest conversation with your doctor to ensure you are getting the best care possible.

Treatment

Chemotherapy

Chemotherapy is a type of cancer treatment that uses drugs to kill cancer cells. It is often used to treat NHL, as it can be effective in shrinking tumors and slowing the growth of cancer cells. Chemotherapy is usually given in cycles, with each cycle lasting several weeks. Side effects of chemotherapy can include nausea, hair loss, fatigue, and an increased risk of infection.

Radiation Therapy

Radiation therapy is another type of cancer treatment that uses high-energy beams of radiation to kill cancer cells. It is often used in combination with chemotherapy to treat NHL. Radiation therapy is usually given in short, daily sessions over a period of several weeks. Side effects of radiation therapy can include fatigue, skin irritation, and an increased risk of infection.

Immunotherapy

Immunotherapy is a type of cancer treatment that uses the body's own immune system to fight cancer cells. It is often used in combination with chemotherapy and radiation therapy to treat NHL. Immunotherapy can be used to boost the body's natural defenses against cancer cells, or to target specific cancer cells. Side effects of immunotherapy can include fatigue, nausea, and an increased risk of infection.

Other Treatments

In addition to chemotherapy, radiation therapy, and immunotherapy, there are other treatments available for NHL. These include stem cell transplants, targeted therapy, and monoclonal antibody therapy. Each of these treatments has its own risks and benefits, and should be discussed with a doctor to determine the best course of action.

Drugs & Medications

Chemotherapy

Chemotherapy is a type of drug treatment that uses drugs to kill cancer cells. It is often used in combination with other treatments, such as radiation therapy. Common chemotherapy drugs used to treat NHL include cyclophosphamide, doxorubicin, vincristine, and prednisone.

Radiation Therapy

Radiation therapy is a type of treatment that uses high-energy X-rays to kill cancer cells. It is often used in combination with chemotherapy to treat NHL. Common radiation therapy drugs used to treat NHL include cobalt-60, cesium-137, and iodine-131.

Targeted Therapy

Targeted therapy is a type of drug treatment that uses drugs to target specific molecules in cancer cells. It is often used in combination with chemotherapy and radiation therapy to treat NHL. Common targeted therapy drugs used to treat NHL include rituximab, alemtuzumab, and obinutuzumab.

Conclusion

Non-Hodgkin's lymphoma is a serious condition that can be life-threatening if not treated properly. Fortunately, there are a variety of drugs available to treat NHL, including chemotherapy, radiation therapy, and targeted therapy. It is important to talk to your doctor about the best treatment options for your specific situation.

Diet

Nutrients to Include in Your Diet

When it comes to eating for Non-Hodgkin's lymphoma, it is important to focus on eating foods that are rich in essential vitamins and minerals. Some of the most important nutrients to include in your diet are:

  • Vitamin A: Vitamin A helps to boost the immune system and reduce inflammation.
  • Vitamin C: Vitamin C helps to protect cells from damage and can help to reduce the risk of infection.
  • Vitamin E: Vitamin E helps to protect cells from damage and can help to reduce inflammation.
  • Selenium: Selenium helps to boost the immune system and can help to reduce the risk of infection.
  • Zinc: Zinc helps to boost the immune system and can help to reduce inflammation.

Foods to Include in Your Diet

In addition to focusing on essential vitamins and minerals, it is also important to include a variety of healthy foods in your diet. Some of the best foods to include are:

  • Fruits and vegetables: Fruits and vegetables are packed with essential vitamins and minerals and can help to reduce inflammation.
  • Whole grains: Whole grains are a great source of fiber and can help to reduce inflammation.
  • Lean proteins: Lean proteins such as fish, poultry, and beans are a great source of essential nutrients and can help to boost the immune system.
  • Healthy fats: Healthy fats such as olive oil, nuts, and avocados are a great source of essential nutrients and can help to reduce inflammation.

Foods to Avoid

In addition to focusing on healthy foods, it is also important to avoid certain foods that can worsen symptoms of Non-Hodgkin's lymphoma. Some of the foods to avoid are:

  • Processed foods: Processed foods are high in unhealthy fats and can worsen inflammation.
  • Sugary foods: Sugary foods can cause blood sugar spikes and can worsen inflammation.
  • Alcohol: Alcohol can weaken the immune system and can worsen inflammation.
  • Caffeine: Caffeine can cause dehydration and can worsen inflammation.

Conclusion

Eating a healthy diet is an important part of managing Non-Hodgkin's lymphoma. It is important to focus on eating foods that are rich in essential vitamins and minerals, as well as avoiding foods that can worsen symptoms. By following a healthy diet, you can help to reduce inflammation and boost your immune system.

Lifestyle

Eat a Healthy Diet

Eating a healthy diet is important for everyone, but especially for those living with Non-Hodgkin's lymphoma. Eating a balanced diet that includes plenty of fruits, vegetables, whole grains, and lean proteins can help you maintain your health and energy levels. Additionally, it is important to stay hydrated by drinking plenty of water throughout the day.

Get Regular Exercise

Exercise is important for everyone, but especially for those living with Non-Hodgkin's lymphoma. Regular exercise can help you maintain your strength and energy levels, as well as reduce stress and anxiety. Talk to your doctor about what type of exercise is best for you and your condition.

Get Enough Sleep

Getting enough sleep is essential for everyone, but especially for those living with Non-Hodgkin's lymphoma. Make sure to get at least 7-8 hours of sleep each night to help your body recover and stay healthy. Additionally, try to stick to a regular sleep schedule to help your body adjust.

Manage Stress

Stress can have a negative impact on your health, so it is important to manage it when living with Non-Hodgkin's lymphoma. Try to find activities that help you relax, such as yoga, meditation, or deep breathing. Additionally, talking to a therapist or counselor can help you manage your stress levels.

Stay Connected

It is important to stay connected with family and friends when living with Non-Hodgkin's lymphoma. Talking to people who understand what you are going through can help you feel supported and less alone. Additionally, staying connected can help you stay positive and motivated.