Narcolepsy

A person with gray hair sleeps on a white desk, their head resting on crossed arms. A small green potted plant and a closed turquoise notebook sit nearby.
10 min read

Narcolepsy is a neurological disorder that affects the control of sleep and wakefulness. It is a chronic condition that can cause excessive daytime sleepiness and sudden, uncontrollable episodes of falling asleep during the day. Narcolepsy can also cause other symptoms, such as cataplexy, sleep paralysis, and hallucinations.

Take the Narcolepsy Assessment

Symptoms

  • Excessive daytime sleepiness (EDS)
  • Sudden and uncontrollable episodes of sleep (cataplexy)
  • Sleep paralysis
  • Hallucinations
  • Automatic behavior
  • Difficulty concentrating
  • Memory problems
  • Depression
  • Anxiety

Excessive daytime sleepiness is the most common symptom of narcolepsy. People with narcolepsy often feel very sleepy during the day, even after getting a full night’s sleep. They may also experience sudden and uncontrollable episodes of sleep, known as cataplexy. During these episodes, the person may experience a sudden loss of muscle tone, which can cause them to collapse or fall asleep suddenly. Sleep paralysis is another common symptom of narcolepsy. During sleep paralysis, the person is unable to move or speak, even though they are conscious. Hallucinations and automatic behavior are also common symptoms of narcolepsy. People with narcolepsy may experience vivid and often frightening hallucinations, as well as episodes of automatic behavior, where they may perform tasks without being aware of what they are doing.

Narcolepsy can also cause difficulty concentrating, memory problems, depression, and anxiety. These symptoms can make it difficult for people with narcolepsy to function normally in their daily lives. If you think you may have narcolepsy, it is important to talk to your doctor. They can help diagnose the condition and recommend treatment options.

Causes

Genetics

Research suggests that genetics may play a role in the development of narcolepsy. Studies have found that people with narcolepsy are more likely to have certain genes than those without the disorder. In particular, mutations in the hypocretin receptor 2 gene have been linked to narcolepsy.

Autoimmune Disorders

Autoimmune disorders occur when the body’s immune system mistakenly attacks healthy cells and tissues. In some cases, this can lead to the destruction of cells that produce hypocretin, a hormone that helps regulate sleep-wake cycles. This can lead to the development of narcolepsy.

Infections

Certain infections, such as the flu, may trigger narcolepsy in some people. This is thought to be due to the body’s immune system mistakenly attacking healthy cells that produce hypocretin.

Brain Injury

Brain injuries, such as a stroke or traumatic brain injury, can damage the areas of the brain that regulate sleep-wake cycles. This can lead to the development of narcolepsy.

Stress

Stress can disrupt the body’s natural sleep-wake cycles, which can lead to the development of narcolepsy. Stress can also trigger narcolepsy in people who are already at risk for the disorder.

Getting a Diagnosis

Polysomnography

Polysomnography is a sleep study that records brain activity, eye movements, muscle activity, and breathing during sleep. It can help diagnose narcolepsy by showing whether the patient has disrupted nighttime sleep, which is a common symptom of narcolepsy. It can also help rule out other sleep disorders.

Multiple Sleep Latency Test

The multiple sleep latency test (MSLT) is a daytime nap study that measures how quickly a person falls asleep during the day. It is used to diagnose narcolepsy by measuring how quickly a person falls asleep and how long they stay asleep. People with narcolepsy usually fall asleep quickly and stay asleep for a long time.

Epworth Sleepiness Scale

The Epworth Sleepiness Scale is a questionnaire that measures how sleepy a person is during the day. It is used to diagnose narcolepsy by measuring how sleepy a person is during the day. People with narcolepsy usually have higher scores on the Epworth Sleepiness Scale.

Genetic Testing

Genetic testing can be used to diagnose narcolepsy by looking for mutations in certain genes that are associated with the disorder. Genetic testing can also help rule out other sleep disorders.

Conclusion

Diagnosing narcolepsy can be difficult, as the symptoms can be similar to other sleep disorders. However, there are several tests that can help diagnose narcolepsy, including polysomnography, the multiple sleep latency test, the Epworth Sleepiness Scale, and genetic testing. If you think you may have narcolepsy, talk to your doctor about these tests.

Questions for Your Doctor

Symptoms

Be sure to tell your doctor about any symptoms you’ve been experiencing. Common symptoms of narcolepsy include excessive daytime sleepiness, sudden sleep attacks, cataplexy (sudden loss of muscle tone), sleep paralysis, and hallucinations. It’s important to be as detailed as possible when describing your symptoms.

Medical History

Your doctor will also want to know about your medical history. This includes any medications you’re taking, any allergies you have, and any other medical conditions you may have. It’s also important to tell your doctor about any family history of narcolepsy.

Sleep Habits

Your doctor will also want to know about your sleep habits. This includes how much sleep you get each night, when you go to bed, and when you wake up. It’s also important to tell your doctor if you have any trouble falling asleep or staying asleep.

Lifestyle Habits

Your doctor may also want to know about your lifestyle habits. This includes any recreational drug use, alcohol consumption, and caffeine intake. It’s also important to tell your doctor about any stressors in your life that may be affecting your sleep.

Treatment Options

Finally, your doctor will want to discuss treatment options. This may include lifestyle changes, medications, or other therapies. Be sure to ask your doctor any questions you may have about the treatment options.

Talking to your doctor about narcolepsy is an important step in getting the help you need. Be sure to discuss your symptoms, medical history, sleep habits, lifestyle habits, and treatment options with your doctor.

Treatment

Medications

Stimulant medications are the most commonly prescribed treatment for narcolepsy. These medications help to increase alertness and reduce daytime sleepiness. Common stimulants used to treat narcolepsy include methylphenidate (Ritalin), dextroamphetamine (Dexedrine), and modafinil (Provigil).

In addition to stimulants, other medications may be prescribed to help manage narcolepsy symptoms. These include antidepressants, such as tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs), and sodium oxybate (Xyrem), a medication used to reduce cataplexy and improve nighttime sleep.

Lifestyle Changes

In addition to medications, lifestyle changes can help to manage narcolepsy symptoms. These include:

  • Getting enough sleep: Aim for 7-9 hours of sleep each night.
  • Exercising regularly: Exercise can help to improve alertness and reduce daytime sleepiness.
  • Eating a healthy diet: Eating a balanced diet can help to improve energy levels and reduce fatigue.
  • Avoiding caffeine and alcohol: Caffeine and alcohol can disrupt sleep and worsen narcolepsy symptoms.

Therapy

Cognitive behavioral therapy (CBT) is a type of psychotherapy that can help to manage narcolepsy symptoms. CBT can help to identify and change negative thought patterns and behaviors that may be contributing to narcolepsy symptoms. It can also help to improve sleep hygiene and reduce stress.

Conclusion

Narcolepsy is a neurological disorder that affects the brain’s ability to regulate sleep-wake cycles. While there is no cure for narcolepsy, there are treatments available to help manage the symptoms. These include medications, lifestyle changes, and therapy. With the right treatment plan, people with narcolepsy can lead full and productive lives.

Drugs & Medications

Types of Drugs for Narcolepsy

The most common drugs used to treat narcolepsy are stimulants, such as methylphenidate (Ritalin) and amphetamines (Adderall). These drugs help to reduce daytime sleepiness and improve alertness. Other drugs used to treat narcolepsy include tricyclic antidepressants, such as imipramine (Tofranil), and selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine (Prozac). These drugs can help to improve nighttime sleep.

Side Effects of Drugs for Narcolepsy

Stimulants used to treat narcolepsy can cause side effects such as insomnia, anxiety, irritability, and decreased appetite. Tricyclic antidepressants and SSRIs can cause side effects such as dry mouth, constipation, and weight gain. It is important to talk to your doctor about the potential side effects of any medications you are taking.

Other Treatments for Narcolepsy

In addition to medications, lifestyle changes can help to improve symptoms of narcolepsy. These include getting regular exercise, avoiding caffeine and alcohol, and getting enough sleep. Counseling can also help to manage the emotional and social aspects of living with narcolepsy.

Diet

What to Eat

Eating a balanced diet that includes plenty of fruits, vegetables, and whole grains can help manage narcolepsy symptoms. Additionally, the following foods may help improve sleep and alertness:

  • High-protein foods, such as eggs, fish, and nuts
  • Complex carbohydrates, such as oatmeal, quinoa, and brown rice
  • Healthy fats, such as avocados, olive oil, and nuts
  • Foods rich in magnesium, such as spinach, pumpkin seeds, and dark chocolate
  • Foods rich in iron, such as lean red meat, beans, and spinach
  • Foods rich in vitamin B-12, such as eggs, fish, and dairy products

What to Avoid

Certain foods and drinks may worsen narcolepsy symptoms. These include:

  • Caffeinated beverages, such as coffee, tea, and energy drinks
  • Alcohol
  • Processed foods, such as chips, candy, and fast food
  • Sugary foods and drinks, such as soda and pastries
  • Foods high in saturated fat, such as red meat and full-fat dairy products

Conclusion

Eating a balanced diet that includes plenty of fruits, vegetables, and whole grains can help manage narcolepsy symptoms. Additionally, certain foods, such as high-protein foods, complex carbohydrates, and foods rich in magnesium, iron, and vitamin B-12, may help improve sleep and alertness. People with narcolepsy should avoid caffeinated beverages, alcohol, processed foods, sugary foods and drinks, and foods high in saturated fat.

Lifestyle

Get Enough Sleep

Getting enough sleep is essential for managing narcolepsy. Aim for 7-9 hours of sleep each night, and take naps during the day if needed. Avoid caffeine and alcohol, as these can interfere with sleep. Establish a regular sleep schedule and stick to it, even on weekends.

Exercise Regularly

Regular exercise can help improve sleep quality and reduce daytime sleepiness. Aim for 30 minutes of moderate exercise each day. Exercise can also help reduce stress and improve overall health.

Eat a Healthy Diet

Eating a healthy diet can help manage narcolepsy symptoms. Avoid processed foods and sugary snacks, and focus on eating whole grains, fruits, vegetables, and lean proteins. Eating small, frequent meals throughout the day can help keep energy levels up.

Manage Stress

Stress can worsen narcolepsy symptoms, so it’s important to find ways to manage stress. Try relaxation techniques such as yoga, meditation, or deep breathing. Spend time with friends and family, and take time for yourself to do activities you enjoy.

Talk to Your Doctor

If lifestyle changes aren’t enough to manage narcolepsy symptoms, talk to your doctor. They may recommend medications or other treatments to help manage the condition.